Kinase Chemistry – Just a year and a half behind the times.

Archive for October 3rd, 2006


Posted by kinasepro on October 3, 2006

Hi Novartis, nice follow on with WO2006101783. Here’s a representative example and their Markush:

Gleevec analog Markush



�Their latest application is a gleevec analog with a pyrrolopyrimidine hinge interaction, which looks nice enough. I wager they’re looking at a potency / selectivity angle. The added imidazo group probably brings in something like TIE2, or IKK… Think they could be a little more vague in your claims though?



>> Update. Ok, ok I guess there is more too it. I didn’t notice on the first pass but they claim to hit some Gleevec resistant strains. Good show.

Posted in bcr abl, gleevec, Novartis | 3 Comments »