KinasePro

iKinase

kinasepro — Sat, 02 Jan 2010 23:51:42 +0000

http://appshopper.com/medical/ikinase

Posted in General Interest

RDEA-119

kinasepro — Wed, 02 Sep 2009 03:22:50 +0000

This PDB entry confirms the structure.

as always, being 18 months behind the times put you 6 months ahead of the curve.

Posted in MEK

p38: Not dead?

kinasepro — Fri, 14 Aug 2009 00:45:54 +0000

Well.. maybe this compound will kill it: Polymorphic Forms / WO/2009/098612 & its from Pfizer no less -

Part Axitinib, part Birb, Part SGX… All MW: 700

Thanks for the email PN.

Posted in p38, Pfizer

AT-131418

kinasepro — Sat, 08 Aug 2009 02:54:00 +0000

Astex has released data about their AKT program, including a PDB, but I have omitted that they appear to have dropped the strutcture of their candidate in WO/2008/110846

Thanks, Ed.

Posted in AKT, Astex

BMS-817378

kinasepro — Sat, 01 Aug 2009 11:53:47 +0000

A comments to BMS-777607 suggest that this structure is the backup:

WO/2009/094427

Posted in BMS, c-Met

ENMD-2076

kinasepro — Sat, 01 Aug 2009 01:35:14 +0000

Its a salt form of ENMD-981693…

Posted in Aurora

AZ’s got PI3K

kinasepro — Thu, 30 Jul 2009 12:20:49 +0000

WO/2009/093972 reminds you of…

Posted in Astra, pi3k

Pi3k @ Bayer

kinasepro — Sun, 26 Jul 2009 02:22:16 +0000

This one hones in on the sulphonamides: (from the former site in CT)

WO/2009/091550; They stuck morpholines out there previously: WO/2008/070150

Posted in Bayer, pi3k

Biogen Nominated…

kinasepro — Tue, 14 Jul 2009 05:10:04 +0000

… A RAF candidate & Sunesis got a milestone,

In August 2004 the companies entered into a collaboration to discover and develop small molecule cancer therapeutics targeting kinases, a family of cell signaling enzymes that play a major role in the progression of cancer. The research term of this collaboration ended in June of 2008. Sunesis retains an option to participate in the co-development and co-promotion of the Raf kinase inhibitor resulting from this collaboration.

Likely derived from WO/2009/006389 & WO/2009/006404

Posted in Biogen, RAF, Sunesis

What do…

kinasepro — Sat, 11 Jul 2009 03:34:04 +0000

…the Bee Gee’s and R406 have in common?

R-788 (a prodrug of R-406) has shown promise in a Ph2b trial. Partner Plz?

still no BMCL

Posted in Rigel, SYK