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Archive for the ‘Wyeth’ Category
Wyeth’s IKK candidate
Posted by kinasepro on October 23, 2008
Posted in IKK, Wyeth | Leave a Comment »
Who’s in CA?
Posted by kinasepro on February 26, 2007
No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:
Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)
Roche talks P38: R1487
And a former Abbot guy is talkinig LCK: A-770041
![O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC](http://img170.imageshack.us/img170/5486/77041cr2.jpg)
all great compounds and yadda yadda, just having a hard time seeing anything new here.
Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »
What’s this I hear?
Posted by kinasepro on February 22, 2007
Is that the sweet sound of Kinase-Blogging Whistling in the Wind? Why yes, yes indeed it is. (link to the original KP entry)
Posted in General Interest, Wyeth | 3 Comments »
Wyeth gets Jak’d up!
Posted by kinasepro on December 30, 2006
via Jak3 but of course – in an underanounced deal with Pharmacopeia:
…Wyeth will pay Pharmacopeia $5 million initially, as much as $9 million of research funding over the next three years, and as much as $175 million for reaching certain goals with the JAK3 kinase inhibitor drug.
While it’s likely they have a few which haven’t published yet, WO/2006/108103 is the most recent PCOP Jak3 application.
![O=C1NC2=C(N=C(N3C4=CC(F)=CC=C4N=C3)N=C2)N1[C@H]5CCC(C6=C5C=CC=C6)=O](http://img174.imageshack.us/img174/9469/jak3pcopqw2.jpg)
They’ve been at this stuff for a while – I reckon since WO/2001/047921 and have a recent Tet Lett on a related series. Check 2HK5 for a clue on how they bind.
>> update 1/25/07 >> US20070021443 Jak3 Pharmacopeia patent application
Posted in Deals, JAK, Pharmacopeia, Wyeth | 3 Comments »
US20060270670
Posted by kinasepro on December 7, 2006
These are Wyeth’s EKB569 analogs which are covalent inhibitors of EGF.
There’s a cystine residue in proximity which adds 1,4 to the butenamide.
US20060270669 Process for making these sorts of things.
US20060270668 Other process for making these sorts of things.
Posted in EGF, Wyeth | 5 Comments »
TPL2 4 Real?
Posted by kinasepro on November 27, 2006
Hey Wyeth, so is TPL2 for real? I see people have been talking up Cot/TPL2/MAP3K8 as another tnf-α inhibiting kinase target, but it seems that nobody else (cept maybe Abbott) seems to have jumped on board yet.
Yes that is a chloride atom there hugging the hinge.
WO2006124692
WO2006124944
Bioorg Med Chem Lett 2006, 6067
Bioorg Med Chem Lett 2005, 5288
(unrelated Abbott tpl2 series: WO2005110410)
ps. Thanks T.S. for the tip that wipo search feature bears much to be loved.
Posted in tpl2, Wyeth | 3 Comments »
US20060247217
Posted by kinasepro on November 4, 2006
Not terribly new, but none-the-less entertaining. This is a divisional application of Wyeth’s 6,6,6 5,6,6 and 6,5,6 tricycles. They are SRC inhibitors, and there’s already a J. Med. Chem.
N#CC1=C(NC2=C(Cl)C=C(Cl)C(OC)=C2)C3=CC4=CC(OC)=C(OCCCN5CCOCC5)C=C4C=C3N=C1
Posted in SRC, Wyeth | Leave a Comment »
