Archive for the ‘VEGF’ Category
Posted by kinasepro on May 20, 2009
So Bayer is in Ph2 with fluoro-sorafenib aka DAST, BAY-734506… Only this time they’re in without Onyx and I gather Onyx is none too happy about this.
The distinct compound is claimed in WO/2005/009961 and the I believe the original Sorafenib app is: WO/2000/042012. What strikes the chemist inventor about a structure like this isn’t usually about who owns it, but if it can really be considered a new invention? The claim structure in the 2000 Sorafenib application can be schematized:
So for the purpose of this discussion the only meaningful definition is the ring designated as “L” and whether or not they claim the fluoride:
Anyhow while this structure and their priority date may be vulnerable to obviousness, all of these applications are assigned to Bayer, and not Onyx, so that disagreement will more likely be resolved based on the wording of the Onyx / Bayer contract. The Onyx press release suggests this very structure was discovered during the collaboration… We’ll see. Given the timing I bet someone saw the structure here on Kinasepro and told Onyx, heh.
Posted in Bayer, RAF, VEGF | 5 Comments »
Posted by kinasepro on April 7, 2009
It’s Bayer’s Ph2 follow-on to Sorafenib. VEGF / RAF yadda yadda… Don’t have the structure, but maybe it’s one of these:
from polymorph apps:
WO/2008/058644 – WO/2008/079968
WO/2008/043446 - WO/2008/079972
& yeh, that is Fluoro-Nexavar…
Posted in Bayer, c-Kit, PDGFR, RAF, VEGF | Leave a Comment »
Posted by kinasepro on March 24, 2009
Eisai’s Ph1 VEGF inhibitor
Posted in Eisai, VEGF | Leave a Comment »
Posted by kinasepro on March 23, 2009
Aveo’s Vegf inhibitor; currently Ph ii in RCC & NSCLC;
Formerly KRN-951 & pM against 1, 2, & 3
Posted in VEGF | 5 Comments »
Posted by kinasepro on March 18, 2009
Vegf, Etc – Boring & Healthy…Tons of Ph2s in HCC but is it better then Sorafenib?
no news is good news?
previously
Posted in Abbott, Genentech, TIE2, VEGF | Leave a Comment »
Posted by kinasepro on March 16, 2009
aka: NVP-AEE788 is Novartis’ VEGF / EGF ‘Nib (&src, &flt, etc.) in Ph1 for the last 6 years… and unceremoniously off the pipeline.
NC2=C3C(NC(C4=CC=C(C=C4)CN5CCN(CC5)CC)=C3)=NC=N2](http://kinasepro.files.wordpress.com/2009/03/aee-788.jpg?w=350&h=247 "aee-788")
Cancer Res
Posted in EGF, Novartis, VEGF | Leave a Comment »
Posted by kinasepro on November 20, 2008
Looks like this one might be coming off the ph3 list…
![O=C(NC1=CC=C(C(C)(C)CN2)C2=C1)C3=CC=CN=C3N([H])CC4=CC=NC=C4](http://img230.imageshack.us/img230/6476/amgfw8.jpg)
Motesanib‘s got “higher early mortality rates“
Posted in Amgen, VEGF | 15 Comments »
Posted by kinasepro on October 7, 2008
Buncha-new Plk1 PDB’s
new c-Met:
new Vegf: 3CJG, 3CJF
Posted in c-Met, PDB, Plk1, VEGF | Leave a Comment »
Posted by kinasepro on September 18, 2007
Big week
2QOH; PPY-A bound to Abl via Ariad; Chem Biol Drug Des
2Z60; PPY-A bound to T315I Abl
(compounds from SGX)
2OH4; Benzimidazole bound to VEGF via GSK JP; J Med Chem
2V7A; PHA-739358 bound to T315I mutant of Abl via Nerviano; Cancer Res
2IN6 Wee1
2IO6 Wee1
Posted in bcr abl, PDB, VEGF | 5 Comments »
Posted by kinasepro on July 20, 2007
Aurora Eh? What can I say, I like’m: WO/2007/079982
Related series, complete w/ a Chem Med Chem.
Posted in Aurora, multi-target, Schering AG, VEGF | 12 Comments »
The distinct compound is claimed in WO/2005/009961 and the I believe the original Sorafenib app is: WO/2000/042012. What strikes the chemist inventor about a structure like this isn’t usually about who owns it, but if it can really be considered a new invention? The claim structure in the 2000 Sorafenib application can be schematized:
So for the purpose of this discussion the only meaningful definition is the ring designated as “L” and whether or not they claim the fluoride:
Anyhow while this structure and their priority date may be vulnerable to obviousness, all of these applications are assigned to Bayer, and not Onyx, so that disagreement will more likely be resolved based on the wording of the Onyx / Bayer contract. The Onyx press release suggests this very structure was discovered during the collaboration… We’ll see. Given the timing I bet someone saw the structure here on Kinasepro and told Onyx, heh.
