‘Nother Triazolopyridazine c-Met app:
Archive for the ‘Sanofi-Aventis’ Category
Sanofi’s got’m too…
Posted by kinasepro on May 13, 2009
Posted in c-Met, Sanofi-Aventis | Leave a Comment »
CN3C(N4C)=NC(C5=NC=NC=C5)=CC4=O)=N1](http://kinasepro.files.wordpress.com/2009/04/sar.jpg?w=500&h=214 "sar")
Aventis in the Aurora arena
Posted by kinasepro on February 4, 2007
A combined US/FR effort results in a novel Aurora chemotype in EP1746097:
This scaffold is not entirely unknown, but it is new for the Auroras afaik. These were likely discovered as hits from an Ambinter or an aptly named Aurora screening library.
Posted in Aurora, Sanofi-Aventis | 7 Comments »
WO2007011065
Posted by kinasepro on January 28, 2007
Mitsubishi has an app covering the intermediates for their GSK3 Sanofi-Aventis stuff. I still think the spiro compounds are sexier, but the morpholines are further explored so here we have a pretty solid looking asymmetric method to make 2-aryl morpholines via CBS reduction:
CCl)C=C1](http://img370.imageshack.us/img370/7310/untitled2kq6.jpg)
CNCC2=CC=CC=C2)C=C1 FC1=CC=C([C@H](OC2)CN(CC3=CC=CC=C3)C2=O)C=C1](http://img252.imageshack.us/img252/4789/mypicture5ii5.gif)
![FC1=CC=C([C@H]2CN(CC3=CC=CC=C3)CCO2)C=C1 FC1=CC=C([C@H]2CNCCO2)C=C1](http://img167.imageshack.us/img167/8666/mypicture6vl3.gif)
Route starts on page 79 example 1, 2 & 5 shown here.
Array might have something to say with how novel the approach is, y’know given how they sell the (rac) stuff?
Posted in GSK3, Mitsubishi, Sanofi-Aventis | 2 Comments »
WO2007006926
Posted by kinasepro on January 25, 2007
Just another pyrimidine series? Maybe, but Sanofi-Aventis has a bunch of these sulfonamides in WO/2007/006926. They’ve got an IKK collaboration Millenium with “MLN0415“ a phase one inhaled IKK-beta inhibitor taking the lead, but this aint that.
![O=S(C1=CC=C(NC2=NC=CC(NC3=CC=C(F)C=C3)=N2)C=C1)(N(C4CCN(CCP(OCC)(OCC)=O)CC4)C[C@H]5CCCN5)=O](http://img404.imageshack.us/img404/513/sfa2xv.jpg)
They’re not all phosphonates, but this subseries has me crooking an eyebrow. Perhaps this is the AVE8680 Sanofi series, but I’d expect this app to have Sxx# given that its a French application… eh… Beats me.
Posted in IKK, Sanofi-Aventis | Leave a Comment »
Got Spiro?
Posted by kinasepro on January 14, 2007
US20070010539 is a GSK3-beta application. This series goes back to ’01, and the pictured spiro compound hit the streets in ’05. Publications on these? Other then an expert opinion (which my library doesn’t carry) and them naming SAR502250 a preclinical development candidate (also in ‘05), I haven’t seen anything. While I don’t relish posting old news, the novel spiro architecture was enough to make KP lift an eyebrow.
C4=CC=CC=C4)C5(CCN(C)CC5)CCN31](http://img296.imageshack.us/img296/6892/sa1ii9.jpg)
Only they know if these spiro compounds are the lead structures, but it looks like a well developed chemical series with an interesting story to be told, and since they’re not talking… I will.
Posted in GSK3, Mitsubishi, Sanofi-Aventis | Leave a Comment »
WO2007000241
Posted by kinasepro on January 10, 2007
Posted in bark, Sanofi-Aventis | Leave a Comment »
