p38: Not dead?

Well.. maybe this compound will kill it: Polymorphic Forms / WO/2009/098612 & its from Pfizer no less -

Part Axitinib, part Birb, Part SGX… All MW: 700

Thanks for the email PN.

PH-797804

In Ph2 for COPD & it’s an atropisomer…(biochem)

Who wants to guess if its R or S

Process App: 20080177077
Backup: 20080269264

Toceranib

aka Palladia, PHA-291639, & SU11654 got its FDA Approval today! Well… In dogs at least:.  It’s for canine mast cell tumors.

yeh, its the pyrrolidine version of Sutent & its the phosphate salt

PF-04217903

This one snuck past me… and into the clinic.  Currently its Ph1 via: WO/2007/132308

this and PF-2341066 both still in the pipeline.

note also WO/2007/138472

R-343

Structure’s a guess from process app: WO/2009/031011

US20080255162

Pfizer’s got PI3K:

previously:

PF-3814735

It’s Pfizer’s Ph1 Aurora inhibitor:

R-343

Rigel gets 5M & some good news from Pfizer:

…Pfizer (NYSE: PFE), has begun a Phase 1 clinical trial of an inhaled formulation of Rigel’s small molecule syk kinase inhibitor, R343, for the treatment of allergic asthma…

Pfizer’s Jnk

SD’s got a series of Jnk1 inhibitors in WO/2007/125405:

First half of the compounds look about like that one, and Jnk1 data is given…
Second half appear discretely in the claims and look more like Jnk3 inhibitors to me.

PF-477736

PF-477736 is Pfizers phase 1 Chk1 inhibitor being given in combination with Gemcitabine. They haven’t confirmed the structure yet, but…

It just so happens that 2007/113671 covers the above Chk1 inhibitor in combination with chemotherapy.   It may be the wrong structure, but till proven thus, it’s on the list.  Click for selectivity.