Kissei’s done a little math on LCK ligands and suggests the stablization owes to those methyl’s.
Cool, yah ,so, umm, like, thats why they gotta be flat.
Archive for the ‘Lck’ Category
CH——-Pi
Posted by kinasepro on October 23, 2008
Posted in General Interest, Lck | 8 Comments »
Plethora ‘o’ PDB’s
Posted by kinasepro on October 14, 2008
GSK’s AKT stuff: 3d0e, 3E8D, 3E87, 3E88; J Med Chem, KP
SGX: Jak2 3E64, 3E63, 3E62, BMCL
Shokat: SRC, SRC, SRC, SRC, PI3K-Gamma, PI3K-Gamma
reminds me of OSI-906 or vice versa
Amgen: P38 J Med Chem; 3DT1
Posted in AKT, CDK2, JAK, Lck, p38, PDB, pi3k | Leave a Comment »
Amgen all TIE2d up?
Posted by kinasepro on March 12, 2007
They describe Tie2 and LCK assays in a number of new apps, but it wouldn’t surprise me to learn a handful of other kinases were running in fear at the site of these things.
app is US20070054916
They’ve also got a C-Met application this week with US20070054903:
Posted in Amgen, c-Met, Lck, TIE2 | 1 Comment »
Who’s in CA?
Posted by kinasepro on February 26, 2007
No, not Canada, A? SF, CA – Here, have a sequal to the Prague entry: This is what you’re missing at YawnFest ’07, err I mean: the MMTC:
Wyeth talks Src/Abl: SKI-606 (American Cyanamid: WO/2000/018740)
Roche talks P38: R1487
And a former Abbot guy is talkinig LCK: A-770041
![O=C(C(N1C)=CC2=C1C=CC=C2)NC3=CC=C(C4=NN([C@H]5CC[C@H](N6CCN(C(C)=O)CC6)CC5)C7=NC=NC(N)=C74)C=C3OC](http://img170.imageshack.us/img170/5486/77041cr2.jpg)
all great compounds and yadda yadda, just having a hard time seeing anything new here.
Posted in Abbott, bcr abl, Lck, p38, Roche, SRC, Wyeth | 4 Comments »
