Cylene’s CK2-α selective inhibitor currently in Ph1:
Ki 0.38 nM
Archive for the ‘CK2’ Category
PDB Update
Posted by kinasepro on November 6, 2007
c-Met + Indolinone: 2RFS; Amgen
c-Met + pyrimidone: 2RFN; Amgen <- Clearly the highlight of the day, but no image from me yet. I’m looking at it wondering where did all the polar contacts go? Peculiar structure, but noteworthy as the first published structure in the xl-880/kirin/bms/genentech/array/methylgene acyl urea isostere genre.
CDK2 + a pyrimidine macrocycle: 2J9M; chemmedchem; Schering AG
CK2: 2RKP: 1.56A
Posted in c-Met, CDK2, CK2, PDB | 5 Comments »
EXEL & CK2
Posted by kinasepro on April 30, 2007
And then theres those 3 applications on CK2 from Exelixis WO/2007/048064, WO/2007/048065, & WO/2007/048066… The latter two with and / or Pim1 & 2 inhibition.
Seems plausible that CK2 could be one of the ‘undisclosed’ targets of the BMS collaboration.
Posted in CK2, Exelixis | Leave a Comment »
