Its a salt form of ENMD-981693…
Archive for the ‘Aurora’ Category
ENMD-2076
Posted by kinasepro on July 31, 2009
Posted in Aurora | 3 Comments »
AMG-900
Posted by kinasepro on June 28, 2009
It’s a Ph1 Aurora A/B/C inhibitor for ‘solid tumors’. Seems likely to be a member of one of the phthalazine series’ WO/2008/124083, WO/2008/057280, WO/2007/100646, or WO/2007/087276.
Posted in Amgen, Aurora | 2 Comments »
TAK-901
Posted by kinasepro on June 18, 2009
TAK-901 is Takeda’s ph1 Aurora B kinase inhibitor & US20090156557 suggests its:
Posted in Aurora, Takeda | 7 Comments »
SNS-314
Posted by kinasepro on May 12, 2009
Posted in Aurora, Sunesis | 1 Comment »
AT-9283
Posted by kinasepro on March 18, 2009
Posted in Astex, Aurora, bcr abl, JAK | Leave a Comment »
PDB Update
Posted by kinasepro on October 29, 2008
Aurora A + 680: 3E5A; Protien Sci
Aurora B: 2VGO; Mol Cell Ther
Posted in Aurora, EphB4, PDB, SRC | 2 Comments »
PF-3814735
Posted by kinasepro on September 5, 2008
It’s Pfizer’s Ph1 Aurora inhibitor:
![O=C(N1[C@H]2C3=CC=C(C=C3[C@@H]1CC2)NC4=NC(NC5CCC5)=C(C=N4)C(F)(F)F)CNC(C)=O](http://kinasepro.files.wordpress.com/2008/09/pf-3814735.jpg?w=248&h=152 "pf-3814735")
Posted in Aurora, Pfizer | Leave a Comment »
VX-680, VX-667: Done
Posted by kinasepro on November 21, 2007
one patient experienced QTc prolongation.
and the follow-on, VX-667:
Failed to meet pharmacokinetic objectives in a Phase 1 trial
Posted in Aurora, Merck & Co., Vertex | 15 Comments »
News of the day
Posted by kinasepro on November 14, 2007
- Ambit grabs 50M in a Series D. Their Lead is AC-220 a ph1 selective Flt3 compound. In WO/2007/109120?
![O=C(N([H])C2=CC=C(C3=CN4C(SC5=CC(N6CCN(C)CC6)=CC=C45)=N3)C=C2)N([H])C1=NOC(C(C)(C)C)=C1](http://img107.imageshack.us/img107/5254/ambitgo4.jpg)
aetiology and limited data in: WO/2005/048953
- Rigel tacks on 3M for the Japanese rights to R-763.
