aka Palladia, PHA-291639, & SU11654 got its FDA Approval today! Well… In dogs at least:. It’s for canine mast cell tumors.
yeh, its the pyrrolidine version of Sutent & its the phosphate salt
Archive for the ‘Approved’ Category
Toceranib
Posted by kinasepro on June 3, 2009
Posted in Approved, Pfizer | 8 Comments »
Tasigna Approved
Posted by kinasepro on October 30, 2007
aka nilotinib, AMN-107 is a Novartis‘ follow-on to Gleevec now approved for CML.
Posted in Approved, bcr abl, gleevec, Novartis | 4 Comments »
$
Posted by kinasepro on October 2, 2007
So what are they worth? TotallyMedicinal’s got the low-low.
TY TM for data: mirrored here.
Posted in Approved | Leave a Comment »
Kinase Inhibitors: On the market
Posted by kinasepro on April 8, 2007
Nothing new to see here, but its about time I got around to it. Here are the currently approved small molecule kinase inhibitors, with a few quick facts and links for each. Xcovery’s got what they’re worth.
Tykerb® , Sprycel®, Sutent®, Nexavar®, Tarceva®, Iressa®, and of course Gleevec®.
Posted in Approved | 2 Comments »
Tykerb ®
Posted by kinasepro on April 8, 2007
Posted in Approved, GSK | Leave a Comment »
Sprycel ®
Posted by kinasepro on April 8, 2007
Sprycel ®, dasatinib, BMS-354825
Discovery: Bristol-Myers Squibb WO/2000/062778
US Approval: June 2006
wiki; PDB: 2GQG; FDA; J Med Chem ’06 6819;
Named after its inventor?
Posted in Approved, BMS | Leave a Comment »
Sutent ®
Posted by kinasepro on April 8, 2007
Sutent ®, sunititnib malate, SU11248
Discovery: Sugen: Provisional filed February 15, 2000 WO/2001/060814. Sugen was bought by Pharmacia-Upjohn which in turn merged with Pfizer.
US Approval: January 2006
wiki; 557795-19-4
Posted in Approved, Pfizer | Leave a Comment »
Nexavar ®
Posted by kinasepro on April 8, 2007
Nexavar ®, sorafenib tosylate, BAY-439006
Discovery: Bayer WO/2000/042012
US Approval: December 2005
Posted in Approved, Bayer | Leave a Comment »
Tarceva ®
Posted by kinasepro on April 8, 2007
Tarceva ®, erlotinib hydrochloride, OSI-774
Discovery: Pfizer WO/1996/30347. Pfizer turned over the rights to OSI to meet U.S. FTC requirements related to Pfizer’s merger with Warner-Lambert in June 2000. The drug is jointly marketted by Genentech, and OSI.
US Approval: November 2004;
PDB: 1M17
Posted in Approved, Genentech, OSI | Leave a Comment »
Iressa ®
Posted by kinasepro on April 8, 2007
Iressa ®, gefitinib, ZD-1839
Discovery: Zeneca (UK) WO/1996/016960
US approval: May 2003
Label change: June 2005
FDA has approved new labeling for Iressa that states the medicine should be used only in cancer patients who have already taken the medicine and whose doctor believes it is helping them. New patients should not be given Iressa because in a large study Iressa did not make people live longer. There are other medicines for non-small cell lung cancer (NSCLC) that have shown an ability to make people live longer.
Posted in Approved, Astra | Leave a Comment »
