KinasePro

Kinase Chemistry – Just a year and a half behind the times.

TargaGen closes…

Posted by kinasepro on July 13, 2007

Closes a 40M series D that is. Kudos Pros. Some of the more recent thiazole apps like US20070161645 appear to my eye to be the Src/Abl backup brigade.

CC1=NC(NC2=NC=C(/C=C/C3=CC(O)=CC=C3)S2)=CC(N4CCNCC4)=N1

wt Abl 1.5 nM
T315I 18 nM

So you like pictures?

2BDJ / 2GQG

About these ads

2 Responses to “TargaGen closes…”

  1. Are you sure those Ariad phosphonate esters aren’t actually dimethylphosphine oxides? [ArP(=O)(CH3)2]? I could be wrong, but Ariad always seemed to be into these kind of unusual functional groups, and I can’t quite remember….

  2. kinasepro said

    They describe both in Chem Biol Drug Des 2006, 46. But now that you mention it, the 2D image above is an ester, while the 3D image is the phosphine-oxide.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

 
Follow

Get every new post delivered to your Inbox.

%d bloggers like this: